Treatment outcomes of transoral robotic and non-robotic surgeries to treat oropharyngeal, hypopharyngeal, and supraglottic squamous cell carcinoma: A multi-center retrospective observational study in Japan

Objectives The aim of this multicenter retrospective cohort study was to compare efficacy and subsequent postoperative treatment between transoral robotic surgery (TORS) any non-robotic in Japanese patients with early oropharyngeal squamous cell carcinoma (OPSCC), hypopharyngeal SCC (HPSCC), or supraglottic (SGSCC). Materials methods Clinical information surgical outcomes were compared early-stage OPSCC, HPSCC, SGSCC who underwent TORS (TORS cohort) those surgery, including videolaryngoscopic (TOVS), endoscopic laryngopharyngeal (ELPS), laser microsurgery (TLM) (non-robotic cohort). data the Head Neck Cancer Registry Japan (registry used validate comparison. main presence positive margins under pathology requirement for therapy, radiotherapy chemoradiotherapy. Results Sixty-eight cohort, 236 1,228 registry eligible study. Patients more likely have tumor disease T2/3 than other cohorts (P<0.001 P=0.052, respectively). had significantly fewer (P=0.018), as well treatment, although difference not significant (P=0.069). In subgroup analysis a total 57 73 171 present OPSCC lateral wall lesions (P=0.003). also (P=0.026), no (P=0.177). Conclusions Our results suggest that leads surgeries. clinical significance may be further validated through all-case surveillance running future.